1. One major research axis centers on the metabolism and health benefits of alternative sugars. While alternative sugars are traditionally considered non-metabolizable, our laboratory explores how these compounds directly and indirectly affect metabolism in tissues. Using multi-omics approaches, we investigate how alternative sugars modulate the metabolism of other nutrients. 

2. A second research focus involves toxicological studies using a humanized mouse model to better reflect human xenobiotic metabolism. Conventional rodent models often show faster clearance of toxicants, limiting translational relevance. To overcome this, we utilize CYP1A1/1A2 humanized mice that replicate human-like metabolism and allow precise assessment of chronic toxicity. Through the model, we examine how exposure to food-derived or environmental toxicants disrupts the AhR-CYP1A axis and induces tissue dysfunctions. 

Overall, my laboratory seeks to bridge the gap between food functionality and toxicity, pursuing a molecular understanding of how dietary components and environmental exposures shape human health. By combining mechanistic insights with a translational animal model and omics technologies, we aim to contribute to the development of scientifically validated functional foods and preventive nutraceuticals.